Living the kind of life that I have, Iโm amazed by the degree to which itโs been a pain-free existence. (Iโm talking physical pain onlyโyou donโt want to hear me talk about the rest.)
This doesnโt make me the best test subject for cannabis-made topical pain relievers. And while I have considered imparting tremendous bodily harm upon myself for the sake of journalism, itโs actually not necessary. As a caregiver in the Oregon Medical Marijuana Program (OMMP) system, I have a number of patients who are unfortunately in near-constant pain from myriad ailments, from chronic to terminal.
The upside is that I sometimes get to share free samples with my patients, and that helps me get a sense of what product works for which condition. Such was the case with Nightingale Remedies.
Nightingaleโs owner and CEO, Patrick Brennan, had worked in the Oregon cannabis industry back in a different era, the pre-Measure 91, OMMP-only days. (Were we ever so young?) Brennan used cannabis to treat a variety of injuries from years of intense snowboarding and skateboarding, resulting in a โchronically out-of-whack backโ and four knee surgeries.
โThis came from necessity,โ says Brennan. โI tried all the other patches, salves, and oils, none which brought me consistent relief and comfort. So I chose to make a product that I believe delivers on the promise of true pain relief.โ
Brennan started by purchasing dozens of cannabis-infused topicals from Oregon and other states with cannabis programs, both recreational and medical. He then deconstructed each product by its ingredient list, drafted a lengthy spreadsheet, and reviewed each oneโs effectiveness with the help of a doctor and a pharmacist. โIt allowed me to toss out a number of ingredients that, while commonly used, had no true pain-relieving value,โ he says.
The productโs long label lists more than 50 ingredients, which Brennan and his team chose to create a true โentourage effect.โ That includes turmeric curcumin, Boswellia serrata, glucosamine hydrochloride, methylsulfonylmethane (MSM), and the cannabinoid CBD. Brennan says the lengthy list serves to address pain in two ways. (Warning: science ahead.)
โStudies have shown that CBD regulates the release of neurotransmitters and central nervous system immune cells to manage both nociceptive and neuropathic pain levels in the body. Nociceptive pain is the most common type of pain, and is caused by the detection of noxious, or potentially harmful, stimuli by the nociceptors around the body. Nociceptors are receptors that are specifically designed to detect stimuli that may cause harm to the body, which may be mechanical, chemical or thermal in nature.
โFor example,โ Brennan continues, โthey may sense when there is physical damage to the skin, muscles, bones, or connective tissue in the body, or when they are exposed to toxic chemicals or extreme temperatures. They usually have a high threshold, but when they are activated, they send electrical signals of pain to the central nervous system and the brain to deliver the perception of pain.โ
(This goes against what Patrick Swayze taught me in Road Houseโโpain donโt hurtโโbut Iโm going to take Brennan at his word.)
How well did Nightingale Remediesโ formula work? To be honest, I was skeptical. Iโve had mixed results using CBD-based topicals, with some patients responding very well, and others receiving next to no relief. Itโs a frustrating exercise for caregiver and patient alike.
So I was floored when I got reports back from users with a near-universal thumbs up. Better still, the cream didnโt simply address one or two conditions, but offered pain relief for those with osteoporosis, rheumatoid arthritis, Parkinsonโs, neuropathy from diabetes, and severe muscle and joint pain. One patient was able to swap out the opioid pain pills being used to treat a back injury.
Bonus: The absence of THC allows the product to be used by those concerned about โgetting highโ from a cannabis, including children. It also allows the cream to be shipped in all 50 states.
Anything that moves those in pain to forgo traditional pharmaceutical offerings is a win for wellbeing, and products with THC and CBD in them are a great start. Becauseโsorry, Patrick Swayzeโpain actually does hurt.

My internet searching found nothing at all about this company or its product, no other reviews,even their Fbook page is pristinely unliked or commented upon. I shall remain skeptical.
It’s the first thing that comes up when you search for them, that makes 0 sense.
https://nightingale-remedies.com/
Marquee, the bolded blue name of the company in the piece is what’s known as a “hyper link” – by clicking on it, it will take you directly to a website. In this case, it’s the website of the product. You can also find it in the comment above this. Or by using Google or other search engines, and typing in the name of the company. Or you can email me and ask about contact info. I can’t help you with their pristine FB page, but as they are a new company, that may explain it. Thanks for reading!